Research Compendium/TB-500
Recovery & RepairResearch OnlyNot For Human Consumption

TB-500

Thymosin Beta-4 fragment · Tβ4 synthetic analogue

Synthetic analogue of thymosin beta-4 with actin-sequestering and pro-angiogenic activity in tissue repair models.

MECHANISM OF ACTION

TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), a 43-amino acid protein ubiquitously expressed in mammalian cells. Its primary mechanism involves G-actin sequestration - binding monomeric actin to regulate cytoskeletal dynamics and promote cell migration. Research also demonstrates upregulation of metalloproteinases (MMPs), anti-inflammatory cytokine modulation, and progenitor cell recruitment. Has been studied in cardiac repair, corneal healing, and dermal wound models.

RESEARCH APPLICATIONS

  • Skeletal muscle and connective tissue repair
  • Cardiac muscle repair post-infarction (preclinical)
  • Corneal and ocular surface healing models
  • Anti-inflammatory modelling (NF-κB pathway)
  • Progenitor/stem cell mobilisation research

RESEARCH HIGHLIGHTS

Cardiac Progenitor Cell Activation

2011

Tβ4 treatment in post-MI mouse models stimulated cardiac progenitor cell differentiation and reduced infarct scar size vs. saline controls.

Ref: Sopko et al., J Mol Cell Cardiol

Corneal Wound Healing

2001

Topical Tβ4 significantly accelerated corneal re-epithelialisation in rabbit models, with proposed mechanism via lamellipodia-forming actin remodelling.

Ref: Sosne et al., Invest Ophthalmol Vis Sci

RESEARCH PROTOCOL NOTES

Research concentration2–2.5 mg per administration in murine models
RouteSC or IM injection
Available formatsVial (2–20mg), Pen, Nasal Spray

Chemical Identity

Molecular FormulaC212H350N56O78S
Molecular Weight4963.5 g/mol
CAS Number77591-33-4
Half-Life (t½)~30–50 hours in animal models
SolubilityHighly water soluble

Storage & Stability

Lyophilised: -20°C, 24+ months. Reconstituted: 2–8°C, use within 21 days. Greater solution stability than BPC-157.

Regulatory Status

No regulatory approval. WADA prohibited under S2 (Peptide Hormones). Research compound in South Africa.

Back to Research CompendiumView Research Compounds →